Technical resources
Insights for better molecular workflows.
Practical guidance for nucleic-acid extraction, PCR, electrophoresis and everyday molecular laboratory troubleshooting — written to help laboratories understand variables, diagnose problems and improve workflow performance.
Featured guide
Troubleshooting starts with the variables you can control.
Our technical resources focus on practical bench decisions rather than generic theory: sample quality, reaction conditions, consumables, workflow setup and downstream performance.
Is Your DNA Good Enough?
NanoDrop, fluorometry and DNA integrity each answer different questions. Learn how to select practical QC checks before PCR, library preparation or sequencing.
Read the guide →Technical library
Practical guidance from the bench.
The library will grow around the questions laboratories ask most often: extraction, clean-up, amplification, electrophoresis, automation and difficult sample types.
matters.
Plant & Soil DNA Extraction Troubleshooting
Polysaccharides, phenolics and humic compounds: identify why difficult samples fail PCR or sequencing.
Read guide →with control.
Scaling Extraction: 24 to 192 Samples
Plan controls, plate layouts, processing time and consistency before taking a workflow to scale.
Read guide →matters.
DNA Integrity for Long-Read Sequencing
Why recovered DNA mass is not enough when fragment integrity and downstream library preparation matter.
Read guide →or input?
PCR Inhibition After DNA Extraction
Use control results, dilution behaviour and specimen history to distinguish PCR inhibition from weak template or assay failure.
Read guide →or columns?
Magnetic Beads vs Spin Columns
Compare separation formats, throughput, practical constraints and downstream suitability before selecting a workflow.
Read guide →extraction.
RNA Degradation Starts Before Extraction
Collection, transport, stabilisation and storage can shape RNA integrity long before purification begins.
Read guide →
Fine-Tuning Your PCR Reactions
Investigate template quality, primer design, reaction conditions and controls when PCR yield or specificity falls short.
Read guide →
Mastering Agarose Gel Electrophoresis
Gel concentration, agarose quality, running buffer and voltage: four variables that strongly influence separation and band quality.
Read Part 1 →
From Ladder Selection to Gel Imaging
Preparation, ladder choice, loading, staining and equipment checks that help turn a technically correct run into a useful result.
Read Part 2 →How we approach technical content
Focus on variables a laboratory can actually change, observe and troubleshoot.
Separate useful general guidance from conditions that depend on the method, reagent or instrument.
Consider upstream sample quality and downstream performance rather than treating each step in isolation.
Technical support
Working through a difficult sample or workflow?
Gene Vantage scientists can help evaluate sample type, extraction format, automation requirements and downstream performance.