Plasma spin columns are specially designed for the rapid and efficient isolation of cell-free DNA (cfDNA), RNA, or proteins from human plasma or serum samples. These columns utilize a silica membrane-based binding matrix housed in a polypropylene spin column, allowing high-yield, high-purity nucleic acid recovery suitable for sensitive downstream applications such as PCR, qPCR, RT-PCR, NGS, and biomarker discovery.
Key Features:
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Column Format: Mini spin column with integrated high-capacity silica membrane for selective binding of nucleic acids from plasma.
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Material: Chemically resistant, medical-grade polypropylene; membrane is optimized for binding DNA/RNA in the presence of chaotropic salts.
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Volume Capacity: Typically supports sample volumes up to 800 µL of plasma per load (depending on protocol).
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Filtration Efficiency: Provides clean eluates with minimal protein, salt, or heme contamination.
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Compatibility: Designed for use with standard microcentrifuges (≥12,000 × g); compatible with vacuum manifolds and automation systems.
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Sterility & Purity: Manufactured under cleanroom conditions; available RNase-, DNase-, and endotoxin-free.
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Ease of Use: Color-coded or transparent housing for easy identification and visual tracking of binding and elution steps.
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Packaging: Available individually wrapped or in bulk packs; includes collection tubes if required.
Applications:
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Extraction of cfDNA or cfRNA from plasma for liquid biopsy workflows
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Isolation of viral RNA from plasma in clinical diagnostics
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Preparation of samples for NGS or qPCR-based mutation detection
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Epigenetic biomarker analysis (e.g., methylated cfDNA)
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Proteomics workflows from plasma-derived proteins
These spin columns are trusted for their reproducibility, high sensitivity, and purity, supporting both manual and semi-automated protocols in diagnostic, biobank, and molecular research environments.
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